Naturally, I ordered the Snake Slayer with the 4.25″ barrel in .45 Colt/.410. I also ordered a 2.5″ barrel in .40 S&W and a 4.25″ barrel in .357/.38Spl. Using the .410 with 3″ Winchester PDX is a kicker. Literally. You maintain control of the gun, but you KNOW the catcher is out of commission. At 10 yards, the man-sized target had all discs and pellets inside the black. The .38 Specials and .357 Mag rounds went downrange easily enough, and I could have shot boxes of them. I figured the .40 S&W was an easily obtainable round, and this WAS a pocket gun… They KICK, almost as much as the .45 Colt’s and .410 PDX’s did. So, if I go to the range, I’ll practice with the .38 Spcl’s and carry with the .410 PDX’s. When hunting, I’ll carry the .410 with #8 for snakes.